Oral fluid testing

The detection methods of oral liquid mainly include the following key aspects:

1. Appearance detection
Appearance detection is the first impression of oral liquid. By observing the color, clarity, suspended matter and other aspects of oral liquid, its stability and possible problems can be preliminarily judged. For example, the phenomenon of discoloration, precipitation, or stratification of oral liquid may mean that there are quality problems with the drug.

2. Filling volume detection
Filling volume detection is one of the important items for evaluating oral liquid preparations. It involves the dosage of drugs and directly affects the therapeutic effect of drugs. According to regulations, the actual filling volume of oral liquid should be consistent with the labeled filling volume. If there is a large deviation, an investigation is required to eliminate potential quality problems.

3. Microbial limit detection
Microbial limit detection is an important indicator for evaluating the sanitary status of oral liquid. By detecting the content of microorganisms such as bacteria, molds, yeasts, etc. in oral liquid, its sanitary status can be judged. If the microbial limit exceeds the standard, it may cause problems such as drug deterioration and corruption, which seriously affect the therapeutic effect of drugs.

4. Content Determination
Content determination is a key indicator for evaluating the effectiveness of oral liquid. By determining the content of active ingredients in oral liquid, it can be understood whether it meets the expected standards. Too low a content may affect the therapeutic effect, while too high a content may cause adverse reactions. When conducting content determination, it should be noted that the effective ingredients of different drugs and their determination methods may be different, such as ultraviolet visible spectrophotometry, high-performance liquid chromatography, etc.

5. pH value detection
The pH value detection is used to evaluate whether the pH value of the oral solution is within the specified range to ensure its stability. Testing the liquid medicine with pH test paper or a pH meter can determine whether it is suitable for human use.

6. Other test items
In addition to the above basic test items, the quality inspection of oral liquid can also cover many other aspects. For example:

Physical and chemical property detection: For some special drugs, physical and chemical property detection may be required to gain a deeper understanding of the chemical properties of the drug.
Pharmacological and toxicological tests: Pharmacological and toxicological tests can evaluate the efficacy and safety of drugs.
Heavy metal detection: Detect heavy metal contamination that may exist in oral liquid, including lead, mercury, arsenic, etc., to ensure the safety of the product.
Stability test: Test the chemical stability of the oral liquid to ensure that it will not decompose or fail during the shelf life.
VII. Testing methods and instruments
A variety of advanced testing instruments and methods are usually used to test oral liquids. For example:

High-performance liquid chromatography (HPLC): used to analyze the content of active ingredients in oral liquids.
Gas chromatography (GC): mainly used to detect volatile components and organic solvent residues.
Atomic absorption spectrophotometer: used to detect heavy metal content.
pH meter: used to measure the pH of oral liquids.
Constant temperature incubator: used for the cultivation and detection of microorganisms.
In summary, the testing methods of oral liquids involve multiple aspects and multiple technical means. Through strict testing, the quality and safety of oral liquids can be ensured, providing consumers with reliable protection.